Research Overview

In recent years, genomic sequencing and systematic analysis have revealed many molecular components that control gene expression at multiple levels, and detailed the myriad of interactions among and between these regulatory modules. However, it remains unclear how these molecular networks operate in time and space to carry out diverse cellular functions. The goal of our lab is to understand how network architecture governs the dynamics and function of regulatory responses in the context of stresses, aging, or diseases. Our lab uses multidisciplinary approaches, integrating biology, engineering and computer science, in our studies. We develop and use novel microfluidics and imaging technologies to quantitatively track the dynamics of molecular processes in single living cells and construct computational models to describe and predict cellular behaviors.